The 2021 Iowa State Cyclones football team represented Iowa State University as a member of Big 12 Conference during the 2021 NCAA Division I FBS football season. Led by sixth-year head coach Matt Campbell, the Cyclones compiled an overall record of 7–6 with a mark of 5–4 in conference play, placing fourth in the Big 12. Iowa State was invited to the Cheez-It Bowl, the Cyclones lost to Clemson. The team played home games at Jack Trice Stadium in Ames, Iowa. Iowa State began the season ranked seventh in the AP poll, the highest preseason ranking in program history. Wiki link