Professional baseball does not constitute interstate commerce since road games are not very profitable, and therefore it is exempt from the Sherman Act's antitrust provisions. This was one of the last antitrust exemptions granted by the Court under the less expansive reading of the Interstate Commerce Clause that saw it as chiefly concerned with the manufacture and shipping of goods across state lines, and the only one that remains in force; Congress has limited some aspects of it but has not repealed it. No other professional sport has been held exempt from antitrust law. Decided May 29, 1922 (argued April 19, 1922). Opinion of the Court: Oliver Wendell Holmes → go there Topic: Businesses/Corporations/Contracts. Federal Baseball Club v. National League, 259 U.S. 200 (1922), is a case in which the U.S. Supreme Court ruled that the Sherman Antitrust Act did not apply to Major League Baseball. Wiki link