La Última Mision World Tour was the farewell concert tour by reggaeton duo Wisin & Yandel supporting their final studio album La Última Misión (2022). The tour commenced on May 27, 2022, in Medellin, Colombia and ended on December 31, 2022, in San Juan, Puerto Rico. The tour consisted of two legs, the first in Latin America and the second leg includes 28 shows in North America, concluding with a headlining record-breaking 14-show run at the José Miguel Agrelot Coliseum in Puerto Rico. They further performed in 2023 as part of music festivals throughout Latin America and North America.